The headquarters of the Central Commission were originally in Mainz (until 1861), and then in Mannheim until 1919. The Treaty of Versailles transferred the headquarters to Strasbourg. They are now located in the former imperial palace, which is now called the Palais du Rhin.
The building was inaugurated in 1888. It serves as the headquarters of both the Central Commission and of the Directorate of Cultural Affairs for Alsace.
The building was designed by the german architect Hermann Eggert in 1882.
It was erected between 1884 and 1888 in the neo-Renaissance style as palace of the emperor, i.e. as residence for the german emperor during his visits in the then german province Alsace-Lorraine. It was used by Emperor Wilhelm II only 5 times up to 1914 and from 1920 it has served as Palais du Rhin, the residence of the CCNR.